Intensive and Critical Care Nursing
Volume 26, Issue 4 , Pages 189-195 , August 2010

International variations in outcomes from sedation protocol research: Where are we at and where do we go from here?

  • Mark O’Connor

      Affiliations

    • Alfred Hospital Intensive Care Unit, Commercial Road, Prahran, Victoria, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 93831453.
  • ,
  • Tracey Bucknall

      Affiliations

    • Cabrini/Deakin Centre for Nursing Research, Burwood, Victoria, Australia
  • ,
  • Elizabeth Manias

      Affiliations

    • Melbourne School of Health Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Level 5, 234 Queensberry Street, Carlton, Victoria 3053, Australia

,Accepted 8 May 2010.

References 

  1. Adam C, Rosser D, Manji M. Impact of introducing a sedation management guideline in intensive care. Anaesthesia. 2006;61(3):260–263
  2. Aitken LM, Marshall AP, Elliott R, McKinley S. Critical care nurses’ decision making: sedation assessment and management in intensive care. Journal of Clinical Nursing. 2009;18(1):36–45
  3. Bellomo R, Stow P, Hart G. Why is there such a difference in outcome between Australian intensive care units and others?. Current Opinion in Anaesthesiology. 2007;20:100–105
  4. Bellomo R, Warrillow SJ, Reades MC. Why we should be wary of single-centre trials. Critical Care Medicine. 2009;37(12):3114–3119
  5. Brattebo G, Hofoss D, Flaatten H, Muri AK, Gjerde S, Plsek PE. Quality improvement report—effect of a scoring system and protocol for sedation on duration of patients’ need for ventilator support in a surgical intensive care unit. British Medical Journal. 2002;324(7350):1386–1389
  6. Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G, Shannon W, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Critical Care Medicine. 1999;27(12):2609–2615
  7. Bucknall TK. The clinical landscape of critical care: nurses’ decision making. Journal of Advanced Nursing. 2003;43(3):310–319
  8. Bucknall T, Manias E, Presneill J. A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit. Critical Care Medicine. 2008;36:1444–1450
  9. Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault P-F, et al. Impact of systematic evaluation of pain and agitation in an intensive care unit. Critical Care Medicine. 2006;34(6):1691–1699
  10. De Jonghe B, Bastuji-Garin S, Fangio P, Lacherade JC, Jabot J, Appere-De-Vecchi C, et al. Sedation algorithm in critically ill patients without acute brain injury. Critical Care Medicine. 2005;33(1):120–127
  11. De Jonghe B, Cook D, Griffith L, Appere-De-Vecchi C, Guyatt G, Theron V, et al. Adaptation to the Intensive Care Environment (ATICE): development and validation of a new sedation assessment instrument. Critical Care Medicine. 2003;31(9):2344–2354
  12. de Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcoholism: Clinical & Experimental Research. 2007;31(7):1224–1230
  13. de Wit M, Gennings C, Jenvey W, Epstein S. Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Critical Care. 2008;12(3):R70
  14. Egerod I. Uncertain terms of sedation in ICU. How nurses and physicians manage and describe sedation for mechanically ventilated patients. Journal of Clinical Nursing. 2002;11(6):831–840
  15. Elliott R, McKinley S, Aitken LM, Hendrikz J. The effect of an algorithm-based sedation guideline on the duration of mechanical ventilation in an Australian intensive care unit. Intensive Care Medicine. 2006;32(10):1506–1514
  16. Endacott R, Benbenishty J, Seha M. Challenges and rewards in multi-national research. Intensive and Critical Care Nursing. 2010;26:61–63
  17. Erdek MA, Pronovost PJ. Improving assessment and treatment of pain in the critically ill. International Journal for Quality in Health Care. 2004;16(1):59–64
  18. Gunning K, Rowan K. Outcome data and scoring systems. BMJ. 1999;319:241–244
  19. Jackson JC, Mitchell N, Hopkins RO. Cognitive functioning, mental health, and quality of life in ICU survivors: an overview. Critical Care Clinics. 2009;25:615–628
  20. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Critical Care Medicine. 2002;30(1):119–141
  21. Jones C, Practical problems of doing research across different cultures: experiences from the RACHEL study. Intensive and Critical Care Nursing, in press.
  22. Jones C, Griffiths RD, Humphris G. Factual memories of intensive care may reduce anxiety post-ICU. British Journal of Anaesthesia. 1999;82(5):793P–1793P
  23. Kress JP, Gehlbach B, Lacy M, Pliskin N, Pohlman AS, Hall JB. The long-term psychological effects of daily sedative interruption on critically ill patients. American Journal of Respiratory and Critical Care Medicine. 2003;168(12):1457–1461
  24. Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. New England Journal of Medicine. 2000;342(20):1471–1477
  25. MacLaren R, Plamondon JM, Ramsay KB, Rocker GM, Patrick WD, Hall RI. A prospective evaluation of empiric versus protocol-based sedation and analgesia. Pharmacotherapy. 2000;20(6):662–672
  26. Magarey JM. Sedation of adult critically ill ventilated patients in intensive care units: a national survey. Australian Critical Care. 1997;10(3):90–93
  27. Magarey JM, McCutcheon HH. ‘Fishing with the dead’—recall of memories from the ICU. Intensive and Critical Care Nursing. 2005;21:344–354
  28. McKinley S. Australian intensive care nursing. Intensive and Critical Care Nursing. 2007;23(6):309–312
  29. Mehta S, Burry L, Martinez-Motta C, Stewart TE, Hallet D, McDonald E, et al. A randomized trial of daily awakening in critically ill patients with a sedation protocol: a pilot trial. Critical Care Medicine. 2008;36(7):2092–2099
  30. Mehta S, McCullagh I, Burry L. Current sedation practices: lessons learned from international surveys. Current Opinion in Critical Care. 2009;25:471–488
  31. Morris PE, Munro CL. All ICUs are not created equal: evaluating pilot studies performed in different environments. AJCC. 2009;18(4):294–297
  32. O’Brien JM, Ali NA, Martin GS, Aberegg SK, Marsh CB, Lemeshow S, et al. Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Critical Care Medicine. 2007;35(2):345–350
  33. O’Connor, M. Sedation of mechanically ventilated patients in Australian and New Zealand intensive care units: nurses’ and doctors’ practices and opinions. Unpublished thesis, The University of Melbourne, Melbourne, 2008.
  34. O’Connor M, Bucknall T, Manias E. Sedation management in Australian and New Zealand intensive care units: doctors’ and nurses’ practices and opinions. American Journal of Critical Care. 2009;online first doi:10.4037/ajcc2009541
  35. O’Connor MA, Bucknall T, Manias E. A critical review of daily sedation interruption in the intensive care unit. Journal of Clinical Nursing. 2008;18:1239–1249
  36. Rattray J, Crocker C. The intensive care follow-up clinic: current provision and future direction?. Nursing in Critical Care. 2007;12(1):1–3
  37. Riker RR, Fraser GL. Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care. Pharmacotherapy. 2005;25(5):8S–18S
  38. Riker RR, Fraser GL. Comfort without coma: changing sedation practices. Critical Care Medicine. 2007;35(2):635–637
  39. Rose L, Nelson S, Johnston L, Presneill J. Decisions made by critical care nurses during mechanical ventilation and weaning in an Australian intensive care unit. American Journal of Critical Care. 2007;16(5):434–444
  40. Schneider Z, Elliott D, LoBiondo-Wood , Haber J. Nursing research: methods, critical appraisal and utilisation. 2nd ed.. Sydney, Australia: Mosby; 2003;
  41. Schweickert WD, Pohlman MC, Pohlman A, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. The Lancet. 2009;373:1874–1882
  42. Sessler CN, Pedram S. Protocolized and target-based sedation and analgesia in the ICU. Critical Care Clinics. 2009;25:489–513
  43. Shann F. Mortality prediction model is preferable to APACHE. BMJ. 2000;320:714
  44. Slomka J, Hoffman-Hogg L, Mion LC, Bair N, Bobek MB, Arroliga AC. Influence of clinicians’ values and perceptions on use of clinical practice guidelines for sedation and neuromuscular blockade in patients receiving mechanical ventilation. American Journal of Critical Care. 2000;9(6):412–418
  45. Suchyta M, Beck C, Key C, Jephson A, Hopkins R. Substance dependence and psychiatric disorders are related to outcomes in a mixed ICU population. Intensive Care Medicine. 2008;34(12):2264–2267
  46. Swart EL, Zuideveld KP, de Jongh J, Danhof M, Thijs LG, Strack van Schijndel RMJ. Population pharamcodynamic modelling of lorazepam and midazolam-induced sedation upon long-term continuous infusions in critically ill patients. European Journal of Clinical Pharmacology. 2006;62:185–194
  47. Weinert CR, Chlan L, Gross C. Sedating critically ill patients: factors affecting nurses’ delivery of sedative therapy. American Journal of Critical Care. 2001;10(3):156–167
  48. Wong C, Burry L, Molino-Carmona S, Leo M, Tessler J, Hynes P, et al. Analgesia and sedative pharmacology in the intensive care unit. Dynamics. 2004;15(Spring):23–26
  49. Wunsch H, Kress JP. A new era for sedation in ICU patients. JAMA. 2009;301(5):542–544

PII: S0964-3397(10)00039-X

doi: 10.1016/j.iccn.2010.05.002

Intensive and Critical Care Nursing
Volume 26, Issue 4 , Pages 189-195 , August 2010